Clinical Evidence

A consistent signal across inflammatory disease

In exploratory cohorts, monomeric CRP tracked with disease in conditions where inflammation plays a central role — including one where standard CRP stays silent.

Cohort summary

Four cohorts, one direction of effect

Across four independent cohorts, mCRP was elevated in patients relative to controls. TODO: cohort sizes — sources differ: COPD n=38 vs n=40. The table uses the conservative ~38 figure; confirm exact enrolment and reconcile with the 2021 JIR publication (DOI: 10.2147/JIR.S320659) before publishing.

Condition	Cohort (approx.)	Direction	Significance
COPD	~38 patients vs controls	mCRP elevated	p < 0.001
Rheumatoid arthritis	~30 patients vs controls	mCRP elevated	p < 0.001
Major depressive disorder	~35 patients vs controls	mCRP elevated	p < 0.001
Obesity (BMI > 30)	~28 patients vs controls	mCRP elevated	p < 0.01

Effect sizes ranged from medium to large. Figures are from exploratory analyses and are being harmonised for publication.

The standout finding

In depression, mCRP spoke when standard CRP did not

The most distinctive research observation came from the MDD cohort, where mCRP was elevated without a corresponding elevation in conventional CRP. If confirmed in larger, prospective studies, this points to inflammation signal that standard testing simply cannot see — a potential window into the neuroinflammation associated with mood disorders.

Why it matters

a marker that decouples from standard CRP could reveal biology that current tests miss. This is a research hypothesis under active investigation — not a diagnostic claim.

Condition detail

Where inflammation is central

COPD

mCRP was elevated in patients versus controls, with a research-stage inverse correlation to lung function (FEV1). Related doctoral research context published in Journal of Inflammation Research, 2021.

Rheumatoid arthritis

Elevated mCRP in active disease, with a research-stage relationship to disease-activity scoring (DAS28).

Major depressive disorder

Elevated mCRP that did not track with conventional CRP — the platform’s most novel signal.

Obesity

Elevated mCRP consistent with metabolic inflammation.

Publications & references

The published record

TODO: full, formatted publication list and links

Munuswamy R., et al. Journal of Inflammation Research, 2021. DOI: 10.2147/JIR.S320659 TODO: authors/citation
Doctoral thesis TODO: public link or availability

Explore collaboration on clinical studies →Read the science →